Skip to main content
Pharma 中文

Clinical Research Services

About us

Yanto Health is a medical statistics consultancy that builds the methodological foundations of clinical research, turning real clinical data into evidence that can be recalculated, verified and traced.

Request an assessmentCompany overview

Company details · Methodological scope · Team responsibilities · Delivery checks

01 Clinical Research

Company overview

Company registration details
Full company name
言拓致优（四川）生物医学研究有限公司 (Yanto Health)
Unified Social Credit Code
91510100MA6CPM2H72
Date of incorporation
10 May 2017
Registered address
Room 1303, Floor 13, Unit 1, Building 2, No. 18 Nanhu Road, Huayang Subdistrict, Tianfu New Area, Chengdu, Sichuan
Registered capital
RMB 59,180,000
Business scope (excerpt)
Medical research and experimental development; engineering and technology research and experimental development; health consulting (excluding diagnosis and treatment); technical services, technology development, technical consulting, technical exchange, technology transfer and technology promotion
Website registration
蜀ICP备2025176616号-1

These are publicly disclosed business registration details, verifiable in the National Enterprise Credit Information Publicity System using the Unified Social Credit Code.

Company history and project records

Company incorporated
10 May 2017Source: business licence registration, verifiable in the National Enterprise Credit Information Publicity System using the Unified Social Credit Code
Projects recorded in the project management system
178 projectsDefinition: projects recorded in the project management system as of 2026-09-10; historical projects predating the system are excluded.
Main support range
Impact factor (IF) 1–5Main support range

Clinical research methodology collaboration

The company was founded in response to two common situations: real clinical data left unused because clinicians lack methodological support; and design flaws discovered only after rejection, when they can no longer be remedied.

We work as clinicians' methodology partners, without operating as a paper mill. Before the first participant is enrolled, we define analytical approaches, endpoints and confounding adjustment strategies. Before submission, we check methodological issues commonly raised by reviewers. Our working standards are aligned with reporting guidelines including Strengthening the Reporting of Observational Studies in Epidemiology (STROBE), Consolidated Standards of Reporting Trials (CONSORT) and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).

— Yanto Health Team

02 Clinical Research

Team and roles

Team size and location
14 professionals, all foreign nationals working overseas; all academic and content work is performed remotely.
Academic roles
5 team members currently hold a total of 17 journal editorial roles; a further 3 serve as reviewers for international journals.
Areas of focus
Editorial roles are concentrated in spinal surgery, neurosurgery, orthopaedics, nephrology and cardiovascular medicine.
Role allocation
Each project has six roles; quality control and compliance reviewers do not write the item they review.

Editorial and reviewer roles are compiled from original CVs supplied by members; see Verification and collaboration for the verification process.

Responsibilities across six roles

Project role allocation
RoleResponsibilities
Account manager (AM)A single, consistent client contact throughout the engagement; any necessary change is notified in writing in advance.
Medical lead (ML)Oversees methodological and medical accuracy; one of the independent signatories before delivery.
Compliance reviewer (CO)Checks material classification, product claims, citations and disclosures item by item; an independent signatory.
Quality control (QC)Does not write the item reviewed and can withhold release.
Writing · editing · design (EX)Assigned by deliverable type, responsible for evidence verification and production.
Project manager (PM)Scheduling, delivery, feedback logs and version control.

On-site work in mainland China is undertaken by a local provider designated by the client or proposed by us. We coordinate, review plans and oversee content and compliance, acting as the external point of contact responsible for execution outcomes.

Editorial role counts and verification limits

The list is compiled item by item from original CVs supplied by members (original CVs collected for 12 members). We have not independently verified these roles with journal editorial offices; 12 of the 17 roles are held by 2 members. Members can provide appointment evidence, or clients can verify directly with the relevant journals. The 17 roles are concentrated in spinal surgery, neurosurgery, orthopaedics, nephrology and cardiovascular medicine. We make no claim of current editorial roles at journals outside these fields.

03 Clinical Research

Delivery checks

  1. 01

    Self-check

    The writer, statistician or editor checks their own work; they cannot authorise release.

  2. 02

    Independent quality control

    A quality controller who did not write the item reviews it and may withhold release.

  3. 03

    Medical and compliance sign-off

    The medical lead and compliance reviewer sign independently and cannot sign for each other. Either can veto release.

Five delivery checks

QC-1 Facts and sources
Claims cite a PubMed identifier (PMID), digital object identifier (DOI) or section number, plus the date checked
QC-2 Numerical reconciliation
Totals are checked programmatically with calculation records retained, rather than by visual inspection
QC-3 Compliance
Check each compliance item; release is withheld while any failed item remains unresolved
QC-4 Language and formatting
Terminology consistency, layout, readability and reference formatting
QC-5 Delivery completeness
Measure pages, items and Chinese characters individually; record the counting basis in the delivery checklist

Delivery is prohibited if any critical defect or unresolved major defect remains. If a problem is found after delivery, immediately stop use and distribution, notify the client in writing, and provide a factual account and correction plan.

04 Clinical Research

Methodology coverage

Members are assigned by methodological expertise; disciplines indicate capability coverage, not project statistics.

12 core methodology areas, each with a reviewer query checklist.

Each methodology area has a checklist of common reviewer queries, reproducible code templates and pre-submission self-check items, reviewed item by item before submission.

  • Meta-analysis and systematic reviews
  • Propensity score matching (PSM)
  • Cox regression and survival analysis
  • Logistic regression and multivariable analysis
  • Diagnostic accuracy analysis
  • Network meta-analysis (NMA)
  • Mendelian randomisation (MR)
  • Mediation analysis and moderation effects
  • Sample size estimation and statistical power analysis
  • Subgroup and sensitivity analyses
  • Dose–response analysis
  • PRISMA / CONSORT / STROBE guidelines

  • Causal inference

    Methods and checks

    Propensity score matching (PSM) / inverse probability of treatment weighting (IPTW) / instrumental variables / regression discontinuity. Three checks: propensity score diagnostics, balance and sensitivity analyses.

  • Survival analysis

    Methods and checks

    Cox PH / Kaplan–Meier survival estimation (KM) / Fine-Gray competing risks / time-dependent covariates. Schoenfeld residuals + proportional hazards checks.

  • Systematic review / meta-analysis

    Methods and checks

    Fixed-effect / random-effects / network meta-analysis. I² + Cochran Q + Grading of Recommendations Assessment, Development and Evaluation (GRADE) evidence quality + publication bias.

  • Prediction models

    Methods and checks

    Receiver operating characteristic (ROC) curves / calibration curves, slope and intercept (Van Calster et al., 2019; H-L is not the primary basis) / decision curve analysis (DCA) for clinical utility / nomograms. 10-fold cross-validation (CV) + 1000 bootstrap resamples for internal validation.

  • Real-world research

    Methods and checks

    Electronic health records (EHRs) / health insurance databases / registry studies. Target trial emulation + immortal time bias + IPTW covariate balance.

  • Nonlinear relationships

    Methods and checks

    Restricted cubic splines (RCS) + threshold effects + interaction tests. Exposure-response curves + cut-off calculations, such as the Youden index.

  • Mendelian randomisation

    Methods and checks

    Two-sample Mendelian randomisation (MR) / polygenic risk scores / sensitivity analyses (MR-Egger / weighted median). Instrument selection and F-statistic checks.

  • Missing data

    Methods and checks

    Multiple imputation by chained equations (MICE) + assessment of missingness assumptions (missing completely at random (MCAR) / missing at random (MAR) / missing not at random (MNAR)). Compare effect estimates before and after imputation.

  • Subgroup and interaction analyses

    Methods and checks

    Prespecified subgroup forest plots + interaction P values + effect modification tests. Control multiplicity and prioritise preregistration.

  • Radiomics

    Methods and checks

    Computed tomography (CT) / magnetic resonance imaging (MRI) feature extraction using PyRadiomics + dimensionality reduction (least absolute shrinkage and selection operator (LASSO) / principal component analysis (PCA)) + multimodal modelling. Dual assessment with area under the curve (AUC) and calibration curves.

  • Network meta-analysis

    Methods and checks

    Indirect comparisons across interventions / node-splitting consistency tests / surface under the cumulative ranking curve (SUCRA) ranking probabilities / funnel plot asymmetry.

  • Reporting guideline self-checks

    Methods and checks

    Item-by-item STROBE (cohort) / CONSORT (randomised controlled trial (RCT)) / PRISMA (meta-analysis) checklists before submission.

Capability coverage across 16 clinical disciplines

CardiologyNeurologyOncologyOrthopaedicsGeneral surgeryRespiratory medicineEndocrinologyNephrologyIntensive careEmergency medicineInfectious diseasesObstetrics and gynaecologyPaediatricsOphthalmologyDermatologyRehabilitation medicine

This list describes capability coverage, not project statistics.

Teams are formed by methodological expertise rather than clinical discipline; multidisciplinary projects are staffed according to methodological needs.

05 Clinical Research

Research ethics and service boundaries

Compliance boundaries

Our involvement in a paper is disclosed truthfully: where our staff meet the authorship criteria of the International Committee of Medical Journal Editors (ICMJE), they are listed as authors under our company's real affiliation; any other contribution is stated in the acknowledgements. Authorship follows the ICMJE criteria: we do not conceal our involvement, do not sell authorship and do not list anyone who did not contribute. We do not ghostwrite, and we do not submit manuscripts without the authors' authorisation. Every deliverable retains decision records to support methodological review by journals and institutions.

Contractual protections

Research information is transferred over HTTPS and stored in a compliant mainland China cloud environment, with access controls limiting visibility. Intermediate data are deleted after the project within the contractual timeframe; data are not disclosed or resold to third parties. See the privacy policy →

Complete evidence trail

Alongside results and figures, deliverables include analysis code (R / SPSS / Stata / SAS) and key decision records, forming a complete evidence trail. Using the same software versions and dependencies, a third-party statistician can rerun the scripts with the data dictionary and random seed to reproduce the results.

Two ways of working together, chosen when the contract is signed

Model 1 · Statistical co-authorship

Manuscript drafting
Our statistical experts analyse the data and prepare the first draft; researchers review, revise and give final approval
Submission and revision
Researchers submit the manuscript and approve each revised version
Disclosure
Authorship under our company's real affiliation; truthful contribution and conflict of interest statements
Eligibility
Available for some projects, assessed before signing; not applicable to degree theses

Model 2 · Guided self-writing

Manuscript drafting
Researchers write the full manuscript; we provide statistical analysis and written comments
Submission and revision
Researchers submit and respond to reviewers; we provide guidance on revision approaches
Disclosure
No authorship; contribution stated in the acknowledgements
Eligibility
All projects

Resident physicians in standardised training and graduate students who choose statistical co-authorship need written consent from their supervisor and their institution. Please check in advance with your institution's research administration office whether co-authorship needs to be registered internally.

Services and engagement boundaries

Service commitments (methodological quality and reproducibility)

  • Study design consulting (Population, Intervention, Comparator and Outcome (PICO) + sample size + analysis plan)
  • Statistical analysis (including code, figures and sensitivity analyses)
  • Full-manuscript language editing (Methods / Results / Discussion)
  • Reviewer responses (structured point-by-point replies)
  • Submission support (journal selection + cover letter + submission system forms)
  • Complete code and decision records (reproducible evidence trail)

Outside our scope (beyond methodological support)

  • Authorship follows the ICMJE criteria: we do not conceal our involvement, do not sell authorship and do not list anyone who did not contribute. We do not ghostwrite, and we do not submit manuscripts without the authors' authorisation.
  • Data falsification: we do not accept requests to alter original data
  • Promises of acceptance by a specific journal: acceptance decisions belong to the journal editorial office
  • We do not ghostwrite, and we do not submit manuscripts without the authors' authorisation. Clients must participate in decisions throughout
  • Data sharing outside the confidentiality agreement

Examples and methodological figures use Illustrative data or reproductions of public data, labelled individually; they do not represent any client project.

Scope of regulatory servicesSee the service overview for the working process

06 Clinical Research

Verification and collaboration

Member disclosure and confidential verification

All members work overseas, and their current roles and editorial appointments are subject to institutional and journal disclosure agreements. Publicly displaying editorial roles on a third-party website may affect their work at journals where they review. This page discloses only team size, location, role allocation and veto arrangements. After a confidentiality agreement is signed, members whose original CVs have been collected can be verified through a client-specified process.

Verifying 5 members and 17 editorial roles

The list is compiled item by item from original CVs supplied by members (original CVs collected for 12 members). We have not independently verified these roles with journal editorial offices; 12 of the 17 roles are held by 2 members. Members can provide appointment evidence, or clients can verify directly with the relevant journals. The 17 roles are concentrated in spinal surgery, neurosurgery, orthopaedics, nephrology and cardiovascular medicine. We make no claim of current editorial roles at journals outside these fields.

Arrangements for on-site work in mainland China

Academic and content work (design, statistics, writing, editing, searching and quality control) is entirely remote and unrestricted by location. We have no in-house mainland China team for on-site execution, visits or placements; a local provider designated by the client or proposed by us undertakes this work. We coordinate, review plans and oversee compliance, acting as the external contact responsible for outcomes. We do not state that we can attend on site.

Project delivery and third-party boundaries

Our members perform methodological and content work, with independent review before delivery by a quality controller who did not write the item. Mainland China on-site execution described above is an exception, and the provider is named in the contract.

Get started · Methodology assessment

Book a methodology assessment

Submit your research question, available data and intended outputs. Reply within 24 hours (business days first), with feasibility feedback, viable statistical approaches and a recommended package in our first response.

Request an assessmentFree assessment · Quote after assessment

Our involvement in a paper is disclosed truthfully: where our staff meet the ICMJE authorship criteria, they are listed as authors under our company's real affiliation; any other contribution is stated in the acknowledgements. Acceptance is decided by the journal editorial office and peer review. We do not promise publication outcomes.